| Numéro |
J. Phys. II France
Volume 4, Numéro 10, October 1994
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|
|---|---|---|
| Page(s) | 1771 - 1784 | |
| DOI | https://doi.org/10.1051/jp2:1994231 | |
J. Phys. II France 4 (1994) 1771-1784
Phase diagram of imprinted copolymers
Vijay S. Pande, Alexander Yu. Grosberg and Toyoichi TanakaDepartment of Physics and Center for Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, U.S.A.
(Received 10 April 1994, accepted 30 June 1994)
Abstract
Recently, a model for the preparation of "protein-like" heteropolymers with a unique and stable ground state has been proposed
and examined computationally. Formally, this model is similar to another recently proposed and computationally examined model
of the evolutionary design of protein-like heteropolymers. Using mean field replica theory, we find, in addition to the freezing
transition of random chains, a transition to the target "native" state. The stability of this state is shown to be greater
than that of the ground state of random chains. The results derived here should at least qualitatively be applicable to known
biopolymers, which are conjectured to be in vivo "designed" by evolution. Furthermore, we present a crude prescription for a laboratory procedure in which chains can be synthesized
in vitro.
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